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vendredi 16 janvier 2015

What The Liposomal Encapsulation Means To Clinical Therapy

By Kristen Baird


The use of liposome in clinical medicine first came to trial in the 1960s, and research and clinical trials that have since followed made sure that this amazing technological evolution can now be applied for both clinical therapy and in other aspect of life. However, the liposomal encapsulation technology (LET) is still in its early stages of development, with little information known to the wider public.

Unlike other methods like in the use of needles for injections, swallowing of tablets, capsules or even syrup where the drug or the substance has to directly pass through the body tissues that are not the direct target, leading to possible reactions, loss of concentration or even interfering with the normal body functions, this method of drug administration employs an ingenious solution to drug administration. In fact, clinical trials have proven that it is better way of treating racehorses without the need of needles or syringes.

In this technology, phospholipid membrane (liposome) is used to encase a prescribed amount of pharmaceutical compounds with the aim of preventing their degradation as they pass through the gastrointestinal tract. This option offers an excellent transfer mechanism that is not available with other drug administration methods. The method is now used in other fields other than in clinical therapies. These include supplement manufacturers, topical moisturizers and the beauty product manufacturers among others.

Phospholipid liposome comes in to withstand the impact of anybody radicals, particularly the enzymes, the body moisture, the alkaline fluids, and the salts within the digestive tract. The compounds being introduced in the body are well protected all the way to the time they are delivered to the targeted organs or the tissue. At this point, a chain reaction takes place, allowing the cells to open up their walls, allowing the compound into the intracellular medium to commence the process of treatment.

The liposomes easily penetrate the cell walls of most living tissues; thereby turning out to be an effective weapon against most pathogens that are disease causing. Its effectiveness is also very highly rated with research findings indicating that 50 grams of Vitamin C delivered directly into the tissue is only as effective as 5 grams of the same delivered through the LET.

Clearly, the advantages of LET over the other forms of drug delivery are many. It allows nutrients to transport power packed natural compounds to the targeted tissues and organs without discomposing the same. This makes a lot of medical and economic sense. Normally, the drugs would be affected by a number of environmental factors as they pass to the tissues. These include oxygen, moisture, differing pH, and enzymes among others. This in addition to factors that affect absorption of nutrients into the body, such as fillers, sugars, binders, and sugar can cause a problem due to incomplete absorption.

The use of phospholipids also comes with numerous benefits to the body. It cuts down on serum lipids, decreases platelet aggregation, bad cholesterol, triglyceride, and increases good cholesterol, and the fluidity of red blood cells gets amplified. In addition to these, it helps boost immunity, improves quality of memory, protects the liver and improves the ability of the body to endure exercise.

Even with all these potential advantages, the studies are not conclusive of the safety of this technology. It is also advisable to design the most effective drug administration that is a cocktail of this and other conventional methods that have been used for centuries to attain the best results.




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